DERIVATIVES OF ( Y , a - DI ( GLYCYLAMINO
نویسندگان
چکیده
a, ar-Di(glycylamino)propionic acid hydrochloride, (NH&H2CONH)2C(CH,)COOH.HCl, is enzymatically hydrolyzed in aqueous extracts of rat kidney to yield, as a maximum, 1 mole of ammonia and 1 mole of pyruvic acid per mole of substrate (1). a-(dl-Chloropropionylamino)-a-(nI,-alanylamino)propionic acid and a:, ac-di(nL-alanylamino)propionic acid hydrochloride are also hydrolyzed by rat kidney, the former substrate yielding a molar ratio of ammonia to pyruvic acid close to unit.y, the latter a ratio close to 1.6 (2). On the other hand, o(, a-di(acet.amino)propionic acid, o(, cr-di(chloroacetylamino)propionic acid, and o!, a-di(dZ-chloropropionylamino)propionic acid are completely resistant (1, 2). Investigations on this novel class of substances have been carried further by observing whether there is any relation between the integrity of the a-amino groups of di(glycylamino)propionic acid and susceptibility to enzymatic attack by a variety of rat tissues. Several new derivatives of di(glycylamino)propionic acid have been synthesized.
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